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[PSCI-01] Solid Dosage Forms: Tablets, Granulation Technology, Compression Defects & Coating
PSCI-01 • 4. PharmaceuticsLearning Objectives
Compare Wet Granulation, Dry Granulation (Slugging/Roller Compaction), and Direct Compression excipients and workflows.; Classify tablet excipients (Diluents, Binders, Superdisintegrants, Glidants, Lubricants, Antiadherents) with functional concentration ranges.; Diagnose and rectify tablet compression and coating defects (Capping, Lamination, Picking, Sticking, Mottling, Orange Peel, Blistering) and apply IP 2022 QC standards.
Chapter Overview & Core Explanation
Tablets are the most widely used dosage form because they provide accurate dosing, high stability, and low manufacturing cost. Transforming raw drug powder into a tablet that stays intact during shipping yet dissolves rapidly in the stomach requires precise balance of excipients and compression physics.
Key Exam & Clinical Takeaways
- Roche Friabilator rotates at 25 rpm for 4 minutes (100 total revolutions) with a drop height of 6 inches; maximum permissible weight loss for conventional compressed tablets is ≤ 1.0%.
- Cellulose Acetate Phthalate (CAP) and Eudragit L100/S100 are anionic enteric polymers that remain unionized and insoluble in gastric acid (pH 1–3) but ionize and dissolve in duodenal fluid (pH 5.5–7.0).